Research - Molecular Hydrogen
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Global Interest in Hydrogen-Based Wellness and Research
What does Molecular Hydrogen do?
According to the Journal of Zhejiang University SCIENCE B - Molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-inflammatory, and anti-ageing effects and contributes to the regulation of autophagy and cell death. As the primary organ for gas exchange, the lungs are constantly exposed to various harmful environmental irritants. Reference - Feb 2022 Journal of Zhejiang University SCIENCE B
Global Interest in Hydrogen-Based Wellness and Research | Countries using Hydrogen Therapy for Medical/Therapeutic Purposes
​​While hydrogen inhalation is not currently recognised as a registered therapeutic treatment in Australia, there is growing international scientific interest in the biological effects of molecular hydrogen.
Across several countries, hydrogen is being studied in research and clinical contexts, particularly in relation to oxidative stress and cellular health. Read more
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China leads with extensive clinical research and applications in areas such as hypertension, diabetes, neurological disorders, and COVID-19 adjunct treatment. In China, hydrogen has been the subject of extensive academic research, with studies exploring its potential in areas such as cardiovascular and metabolic health, as well as supportive applications in clinical settings.
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Japan is widely regarded as an early leader in hydrogen research, with universities and medical institutions investigating hydrogen-rich water and inhalation in relation to oxidative stress, metabolic function, and neurological health.
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In South Korea, hydrogen therapy has been used in anti-inflammatory treatments, metabolic syndrome, and rehabilitation and recovery-focused applications.
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The United States interest lies with clinical trials focused on Parkinson’s disease, metabolic disorders, and inflammation.
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While Germany explores its potential use for chronic diseases and supportive cancer care, France researches hydrogen’s potential to reduce oxidative damage and inflammation. These scientific communities are exploring the potential use of hydrogen therapy - hydrogen’s antioxidant properties, its relevance to cellular stress, chronic diseases, and inflammatory pathways.
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Additional research activity has been reported in Taiwan, with studies focusing on hydrogen-rich water and its relationship to metabolic and neurological function.
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Important Note
The information above reflects international research interest and scientific exploration, not established or approved medical treatments in Australia.
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Hydrogen inhalation devices offered in Australia are intended for general wellness purposes only and are not designed to diagnose, treat, cure, or prevent any disease.
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Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications
Abstract
Persistent oxidative stress is one of the major causes of most lifestyle-related diseases, cancer and the aging process. Acute oxidative stress directly causes serious damage to tissues. Despite the clinical importance of oxidative damage, antioxidants have been of limited therapeutic success. We have proposed that molecular hydrogen (H2) has potential as a “novel” antioxidant in preventive and therapeutic applications [Ohsawa et al., Nat Med. 2007: 13; 688-94]. H2 has a number of advantages as a potential antioxidant: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H2. There are several methods to ingest or consume H2, including inhaling hydrogen gas, drinking H2-dissolved water (hydrogen water), taking a hydrogen bath, injecting H2-dissolved saline (hydrogen saline), dropping hydrogen saline onto the eye, and increasing the production of intestinal H2 by bacteria. Since the publication of the first H2 paper in Nature Medicine in 2007, the biological effects of H2 have been confirmed by the publication of more than 38 diseases, physiological states and clinical tests in leading biological/medical journals, and several groups have started clinical examinations. Moreover, H2 shows not only effects against oxidative stress, but also various anti-inflammatory and anti-allergic effects. H2 regulates various gene expressions and protein-phosphorylations, though the molecular mechanisms underlying the marked effects of very small amounts of H2 remain elusive. Read more of this Japanese study
Keywords: Anti-inflammation, antioxidant, hydrogen medicine, medical gas, mitochondria, oxidative stress, ischemia-reperfusion, ROS.